Our laboratory investigates the cell biological basis of inflammation and wound healing with special emphasis on leukocyte-endothelial interactions. The...

A major area of our interest is how eukaryotic cells sense and respond to stress in the form of damage to their genetic material. When cells incur DNA...

Our lab focuses on the molecular nature of interactions between microbial pathogens and the host. Pathogenic bacteria have evolved complex mechanisms to...

The overarching goal of the Jost lab is to define the molecular mechanisms of host-microbiome communication using a combination of systematic CRISPR...

The main focus of this laboratory is to elucidate the role of ATP and adenosine receptor signaling in immune cell activation. We have discovered that...

Research in our laboratory is focused on understanding how bacterial pathogens co-opt eukaryotic host cell processes to promote infection and cause...

The Lieberman laboratory studies cytotoxic T lymphocytes and their role in infection and tumor immunity. They study the molecular pathways used by killer...

Our laboratory focuses on the engineering of human monoclonal antibodies for their use in discovery research and as drugs for the treatment of human...

CD4+ T cell Tolerance

CD4+ T lymphocytes comprise a principal component of the adaptive immune system. These cells recognize processed antigens...

The Smillie Lab uses systems approaches to understand the mechanisms of host-microbiome interactions. Our research interests are broad, spanning mucosal...

Harness the tools and design principles of synthetic biology to develop novel therapies that can overcome key challenges in cancer immunotherapy...