Innate immunity in the respiratory tract is exquisitely complex and tightly regulated, surveying 10,000 liters of air a day. While canonical pattern-...

By the time we see patients in the clinic, pathology is usually established, and the flames of inflammation are already burning. What keeps inflammation...

Our laboratory investigates the cell biological basis of inflammation and wound healing with special emphasis on leukocyte-endothelial interactions. The...

The function of many proteins is regulated by post-translational modifications. One such modification is citrullination, which converts peptidylarginine...

The Early Life Development of the Immune System

The main focus of the Jain lab is to understand how immunity develops in early life. In utero,...

Chemokines and Lipid Chemoattractants in Normal Physiology and Disease

Research in my laboratory focuses on understanding the role of...

Research in the Sage Lab focuses on understanding how the immune system regulates B cell responses and antibody production. Antibodies clear harmful...

The overall mission of this laboratory is to determine the mechanism of “crosstalk” between colonizing bacteria and the developing human intestine immune...

Inflammation is a protective response to noxious stimuli that originate from infections and injured tissues. The inflammatory process triggered in...