A major area of our interest is how eukaryotic cells sense and respond to stress in the form of damage to their genetic material. When cells incur DNA...

Mucosal Immunobiology

The mucosal barriers of the body facilitate the arduous task of promoting symbiosis with the resident microbiota while...

Research in our laboratory is focused on understanding how bacterial pathogens co-opt eukaryotic host cell processes to promote infection and cause...

Our research focuses on algorithm development and integrative mining from high throughput data to understand gene regulation in cancer biology. We...

Though it has historically focused on fundamental biological questions, the Novina lab places a significant emphasis on identifying unmet medical needs...

The vertebrate immune system is capable of specifically recognizing and responding to an enormous number of antigens. The interaction with antigen is...

Our group is devoted to investigating the way in which the functional, chemical and structural plasticity of neurons contributes both to the normal...

The primary research goal of the Xavier Laboratory at Massachusetts General Hospital and the Broad Institute is to discover and understand the function of...