# Catherine Ju-Ying Wu Professor of Medicine ![wu_catherine.jpg](/sites/g/files/omnuum5411/files/styles/hwp_4_5__480x600/public/immunologyphd/files/wu_catherine.jpg?itok=cybFZmv2) location\_on Dana Farber Cancer Institute Dana Building, Room 520C 44 Binney St. Boston, MA 02115 smartphone [617-632-5943](tel:617-632-5943) email laptop\_windows [Lab website](http://wulab.dfci.harvard.edu/) laptop\_windows [Publications](https://pubmed.ncbi.nlm.nih.gov/?term=Wu+CJ&cauthor_id=28678778) Dr. Wu's laboratory focuses on dissecting the underlying mechanisms of pathobiology of chronic lymphocytic leukemia (CLL) as a means to more rationally generate effective therapies, including immune-based treatments, for this common adult leukemia. She has been principal investigator of several center-initiated clinical trials, including an ongoing study that examines the effects of a personal whole tumor cell-based vaccine on outcomes following allogeneic hematopoietic stem cell transplant for the treatment of CLL. A major priority of her studies is the identification of tumor-specific antigens that would allow effective tumor targeting without collateral toxicity. She has been using exome and transcriptome sequencing technologies to identify unique mutated leukemia antigens that arise from individual-specific genetic alterations within a tumor and that could be potentially targeted immunologically, thus paving the way for developing personalized tumor vaccines. Through large-scale genome analysis of chronic lymphocytic leukemia, her laboratory has further discovered key mutated genes and pathways involved in CLL. Other ongoing studies in her laboratory focus on: (a) systematic analyses to couple tumor genotype with phenotype; (b) understanding CLL tumor heterogeneity; and (c) mechanistic studies of novel CLL driver genes. - ## Experimental Approach [Genomics](/experimental-approach/genomics) - ## Organism [Human](/organism/human) [Mouse](/organism/mouse) [Rat](/organism/rat) - ## People [Executive Committee of Immunology](/people/executive-committee-immunology) [Faculty](/people/faculty)