Daniel G. Tenen

Daniel G. Tenen

Professor of Medicine
Daniel G. Tenen

I was born and raised in Southern California, attended UCLA with a major in Applied Math and Physical Chemistry and Harvard Medical School, with postdoctoral research training in the laboratory of David Livingston at Dana Farber Cancer Institute, as well as clinical training with a residency in internal medicine at Brigham and Women’s Hospital and Board Certification in Medical Oncology at Dana Farber. I established my own independent laboratory in 1984 at Beth Israel Deaconess Medical Center, Harvard Medical School, and also since 2008 at the Cancer Science Institute Singapore, where I served as founding Director until 2020.

For the past 38 years my lab has studied gene regulation in normal differentiation and cancer, initially with a focus on myeloid development and acute myeloid leukemia (AML). My laboratory has contributed to understanding the role of transcription factors in cell differentiation and disruption of these pathways in leukemia, lung cancer, and liver cancer. Current efforts include basic studies understanding gene regulation with an aim to manipulate gene expression in in normal and cancer stem cells as well as exploiting differences as a basis for targeted stem cell therapy. In addition to my research accomplishments, I have mentored many graduate students and postdoctoral fellows, many of whom are now full professors. I have served on many review boards, including NIH Study Sections and the Special Emphasis Panel which reviews candidates for the NCI Outstanding Investigator Award.

In addition to my studies on the role of transcription factors (DNA binding proteins) in normal hematopoiesis and leukemia, in the last decade I have in addition studied the role of nuclear long noncoding RNAs in mRNA transcription, epigenetic memory, DNA methylation, DNA replication, and cancer.

In addition, since 2005 I have collaborated with Li Chai on the role of the stem cell oncofetal protein SALL4 in leukemia and solid tumors, especially liver cancer.

Contact Information

Department of Medicine, Harvard Medical School
Hematology/Oncology Division, BIDMC
Center for Life Sciences Room 437
3 Blackfan Circle
Boston, MA 02115
p: 617-416-7740