Adaptation to change is fundamental to living things. Our genome might encode instruction on how organs function and interact, but the choices we make and the environments we inhabit profoundly shape the nature of those interactions. We spend a third of our lives asleep. When we are awake, we eat, move around, and respond to external stressors. Multiple human studies, as well as our personal experience, teach us that a good night's sleep, a healthy diet, regular exercise, and stress management will keep us healthy and may prolong our lives. But how? The overarching theme in the lab is grounded in the idea that leukocytes, the white blood cells dispersed throughout all organs, are conduits of organ systems that engineer the body's response to lifestyle. Our physiology adapts as our lifestyle fluctuates, and we seek to understand the nature of those shifts through a leukocyte lens.
Current projects in the lab include: (i) defining the salience network in the brain that orchestrates tailored leukocyte shifts during acute stress; (ii) investigating how chronic stress perturbs microglial function in the context of Alzheimer's Disease; (iii) exploring how sleep reprograms hematopoiesis; (iv) elucidating how caloric restriction and fasting alter monocyte and eosinophil metabolism and migratory dynamics. Collectively, these studies seek to understand how the quantity and quality of our environmental engagements influence us.
Simches Research Building, Room 5-216
185 Cambridge Street
Boston, MA 02114