Francis W. Luscinskas

Francis W. Luscinskas

Professor of Pathology
Francis W. Luscinskas

The research projects in my laboratory study innate and adaptive immune cell interactions with one another during antigen (Ag) priming of T cells, and the mechanisms underlying innate and adaptive immune cell adhesion to and transmigration across vascular endothelium employing in vivo murine and in vitro human cell models. Our focus is to understand the role of CD47 and its ligands, SIRPα and SIRPγ and LFA-1 and VLA-4 integrins in innate and endothelial cell interactions. Our projects employ in vivo models of inflammation and cancer. Inflammation models include Ag-dependent leukocyte activation and recruitment, DC priming of T cells, Experimental Autoimmune Encephalomyelitis (both MOG induced EAE and Relapsing-EAE) and atherosclerosis in collaboration with Andrew Lichtman‘s laboratory at BWH and a dermal air pouch). Our work in cancer biology focuses on the role of CD47 as a therapeutic for hematological cancer in collaboration with the Weinstock lab at Dana-Farber Cancer Institute.

Our laboratory consists of 2 Research Fellows and two senior Research Scientists who use a combination of immunological, biochemical and molecular biological strategies in our in vivo and in vitro models. We have developed a valuable in vitro model that allows direct microscopic examination of live leukocyte - endothelial and T cell- DC interactions under static or defined laminar fluid shear stress conditions. We are supported by NIH awards.

Key Words: CD47; SIRP; endothelium; T cell; monocytes; adhesion; inflammation.

Contact Information

Harvard Medical School
NRB, Room 752P
77 Avenue Louis Pasteur
Boston, MA 2115
p: 617-525-4337

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