#  Jennifer Guerriero 

Assistant Professor of Surgery

 

 

 



   ![guerriero_jennifer.jpg](/sites/g/files/omnuum5411/files/styles/hwp_4_5__480x600/public/immunologyphd/files/guerriero_jennifer.jpg?itok=z_pepN9E) 

 



 

 location\_on Brigham and Women's Hospital Thorn Research Building 407 20 Shattuck Street Boston, MA 02115 

 email [mailto:jguerriero@bwh.harvard.edu](mailto:mailto:jguerriero@bwh.harvard.edu) 

 laptop\_windows [Lab Website](https://guerrierolab.bwh.harvard.edu/) 

 laptop\_windows [Publications](https://www.ncbi.nlm.nih.gov/myncbi/1Xsuq5pG3v9/bibliography/public/) 

 

 



 

The major goal of the Guerriero lab is to accelerate breast cancer immunotherapy by harnessing tumor associated macrophages. To date, immunotherapy has largely focused on recruiting and activating anti-tumor T cells, which has shown tremendous responses in some types of cancers, but we know that not all patients and not all cancer types benefit from T cell targeted approaches. Macrophages are highly prevalent in solid tumors and function to promote cancer cell survival and proliferation and can also inhibit anti-tumor T cells responses. Therefore, the Guerriero Lab aims to target macrophages to design clinically effective strategies to promote T cell activation and weaken the immune-suppressive tumor microenvironment to improve immunotherapy response rates in breast cancer patients. The lab is particularly interested in identifying tumor-promoting tumor macrophages in breast tumors before and after therapy, elucidating their molecular and metabolic regulation that promotes immune suppression and therapy-resistance and determining how tumor macrophage phenotype, diversity, metabolism and function can be modulated for anti-tumor responses. The lab is working to perform in-depth analysis of animal models and patient samples to efficiently guide rational use and development of immunotherapy modalities for the treatment of breast cancer.

 

 

 





 

 

- ## Experimental Approach
    
     [Cellular Immunology](/experimental-approach/cellular-immunology) [Developmental Immunology](/experimental-approach/developmental-immunology) [Lymphocyte Biology](/experimental-approach/lymphocyte-biology) [Molecular Immunology](/experimental-approach/molecular-immunology)
- ## Field of Study
    
     [Antigen Presentation / Processing](/field-study/antigen-presentation-processing) [Antigen Receptors](/field-study/antigen-receptors) [B Cell](/field-study/b-cell) [Cancer Immunology](/field-study/cancer-immunology) [Chemokines](/field-study/chemokines) [Clinical Immunology](/field-study/clinical-immunology) [Immunotherapy](/field-study/immunotherapy) [Innate Immunity](/field-study/innate-immunity) [Myeloid Cells](/field-study/myeloid-cells) [T Cells](/field-study/t-cells)
- ## Location
    
     [Brigham & Women's Hospital](/location/brigham-womens-hospital)
- ## Organism
    
     [Human](/organism/human) [Mouse](/organism/mouse)
- ## People
    
     [Faculty](/people/faculty)