# Jon Christopher Aster Professor of Pathology ![aster_jon.jpg](/sites/g/files/omnuum5411/files/styles/hwp_4_5__320x400/public/immunologyphd/files/aster_jon_0.jpg?itok=QL4KFsns) location\_on Brigham and Women's Hospital NRB Building, Room 652E 77 Avenue Louis Pasteur Boston, MA 02115 smartphone [617-525-4370](tel:617-525-4370) email laptop\_windows [Lab Website](https://asterlab.bwh.harvard.edu/) laptop\_windows [Publications](https://pubmed.ncbi.nlm.nih.gov/?term=aster%20jc[author]) The Aster laboratory primarily studies Notch signaling in cancer. Ongoing projects seek to understand through use of ChIP-Seq and other comprehensive genome-wide approaches how Notch regulates the genomes of leukemia cells; how Notch activity is coordinated at the level of the genome with other transcription factors involved in T cell development and T cell transformation, as well as the components of the basal transcriptional machinery and regulators of histone marks; how post-translational modifications regulate Notch; and how Notch effects on leukemia cells are modified by interactions with bone marrow stromal cells. These studies are being conducted within the context of several multi-investigator projects, which foster close collaborations with investigators using structural, chemical, bioinformatic, and animal modeling approaches to study physiologic and pathophysiologic Notch signaling. - ## Experimental Approach [Cellular Immunology](/experimental-approach/cellular-immunology) [Lymphocyte Biology](/experimental-approach/lymphocyte-biology) [Molecular Immunology](/experimental-approach/molecular-immunology) [Structural Biology](/experimental-approach/structural-biology) - ## Field of Study [Signal Transduction](/field-study/signal-transduction) [T Cells](/field-study/t-cells) [Transcription and Gene Regulation](/field-study/transcription-and-gene-regulation) - ## Location [Brigham & Women's Hospital](/location/brigham-womens-hospital) - ## Organism [Bacteria](/organism/bacteria) [Human](/organism/human) [Mouse](/organism/mouse) [Rat](/organism/rat) - ## People [Faculty](/people/faculty)