#  Dr. Joseph Gerard Sodroski 

Professor of Microbiology 

 

 

 



   ![sodroski](/sites/g/files/omnuum5411/files/styles/hwp_4_5__480x600/public/2025-02/29516.jpg?itok=vhS3bUVc) 

 



 

 location\_on CLS Building, Room 1010 

 smartphone [617-632-3470 ](tel:617-632-3470 ) 

 email [joseph\_sodroski@dfci.harvard.edu](mailto:joseph_sodroski@dfci.harvard.edu) 

 laptop\_windows [Lab Website](https://www.dfhcc.harvard.edu/insider/member-detail/member/joseph-g-sodroski-md/) 

 laptop\_windows [Publications](https://pubmed.ncbi.nlm.nih.gov/?term=Sodroski%2C+Joseph+G&sort=date) 

 

 



 

The major interests of the laboratory are the early events in human immunodeficiency virus (HIV-1) infection. Understanding and blocking these early events are critical to interrupting HIV-1 transmission and changing the course of the global AIDS pandemic. The laboratory studies HIV-1 entry into cells, a process that is mediated by the viral envelope glycoproteins. These glycoproteins bind receptors on the target cell and fuse viral and cell membranes. The conformational transitions of the HIV-1 envelope glycoproteins that contribute to virus entry are being characterized. The laboratory is devoted to understanding HIV-1 entry at the molecular level, and identifying and characterizing inhibitors. The interaction of small-molecule entry inhibitors and neutralizing antibodies with the HIV-1 envelope glycoproteins is being studied.

In virus-producing cells, expression of the HIV-1 envelope glycoproteins results in cytopathic effects. These toxic effects result from the membrane-fusing activity of the HIV-1 envelope glycoproteins, which results in damage to the host cell membranes. The contribution of these processes to the depletion of CD4-positive T lymphocytes in vivo is being studied.



 

 

 





 

 

- ## Experimental Approach
    
     [Immunochemistry](/experimental-approach/immunochemistry) [Molecular Immunology](/experimental-approach/molecular-immunology) [Structural Biology](/experimental-approach/structural-biology)
- ## Field of Study
    
     [Immunodeficiency](/field-study/immunodeficiency) [Innate Immunity](/field-study/innate-immunity) [Signal Transduction](/field-study/signal-transduction) [Structural Immunology](/field-study/structural-immunology) [Vaccines](/field-study/vaccines)
- ## Location
    
     [Dana Farber Cancer Institute](/location/dana-farber-cancer-institute)
- ## Organism
    
     [Non Human Primates](/organism/non-human-primates) [Viruses](/organism/viruses)
- ## People
    
     [Faculty](/people/faculty)