K. Frank Austen

K. Frank Austen

Astrazeneca Professor of Respiratory and Inflammatory Diseases in the Department of Medicine
K. Frank Austen
The central focus of the laboratory continues to be on the molecular and cellular biology of the mast cell, the pathways of arachidonic acid metabolism to cysteinyl leukotrienes and prostanoids, and the cytokine regulation of the action of each of these components of allergic inflammation. As there is substantial evidence that innate signals are particularly prominent in allergic diseases, there is increasing attention to the adjuvants within the household allergens that accompany the immunogenic epitopes and on the priming or even circumvention of DC responses by innate effectors such as basophils, mast cells, eosinophils and epithelial cell derived cytokines. 

Contact Information

Brigham and Women's Hospital
Department of Medicine; Division of Rheumatology, Immunology and Allergy
Building for Transformative Medicine
60 Fenwood Road, 5th Floor, Room 5002X
Boston, MA 02115
p: 617-525-1300