#  Kevin Wei 

Assistant Professor of Medicine, Harvard Medical School

 

 

 



   ![Wei](/sites/g/files/omnuum5411/files/styles/hwp_4_5__480x600/public/2025-12/Kevin%20Wei%20profile.jpg?itok=LOtB2XxW) 

 



 

 location\_on Wei lab 60 Fenwood Road, BTM 6016CC 

 email <kwei@bwh.havard.edu> 

 laptop\_windows [Web Address](https://kevinweilab.com) 

 

 



 

Description of Research:

My laboratory at Brigham and Women’s Hospital focuses on deciphering the role of stromal cells in inflammatory and fibrotic diseases. Our approach integrates single-cell transcriptomics, spatial transcriptomics, and patient-derived organoids to define key stromal cell pathways relevant to chronic inflammatory diseases.

*Project 1. Fibroblast pathology in rheumatoid arthritis (RA)*. Fibroblasts are joint mesenchymal cells that perpetuate chronic inflammation and degrade joint tissues. A therapeutic approach that specifically targets fibroblasts holds the promise of preventing joint tissue damage while minimizing unwanted side effects of immune suppression. However, a major challenge in therapy targeting fibroblasts is the lack of knowledge regarding their functional diversity. I played a significant role in defining stromal cell subtypes in joint synovial tissues. I am the senior author of a study that characterizes the molecular basis of fibroblasts driving treatment failure in RA (Bhamidipati and McIntyre et al., accepted in *Nature Immunology*). Together, these studies provide a new paradigm in understanding fibroblast biology and uncover novel stromal cell targets for the treatment of rheumatoid arthritis.

*Project 2. Spatial reconstruction of inflammatory diseases.* Using a “disease reconstruction” approach, our laboratory employs cutting-edge spatial transcriptomic technologies to deconvolute tissue pathology in chronic inflammatory diseases, aiming to identify new pathologic pathways that may be targeted therapeutically. As a member of the NIH Accelerating Medicines Partnership Autoimmune and Immune-Mediated Disease (AMP-AIM), I spearheaded studies using spatial transcriptomics to define cellular networks in inflammatory diseases. These studies contribute to a new understanding of cellular organization in organ tissue affected by chronic inflammatory disease.



 

 

 





 

 

- ## Experimental Approach
    
     [Cellular Immunology](/experimental-approach/cellular-immunology) [Genomics](/experimental-approach/genomics)
- ## Field of Study
    
     [Autoimmunity](/field-study/autoimmunity) [Inflammation](/field-study/inflammation) [Stromal Cells](/field-study/stromal-cells)
- ## Location
    
     [Brigham &amp; Women's Hospital](/location/brigham-womens-hospital)
- ## Organism
    
     [Human](/organism/human)
- ## People
    
     [Faculty](/people/faculty)
- ## Year Entered Program
    
     [2025](/year-entered-program/2025)