Andrew David Luster
Chemokines and Lipid Chemoattractants in Normal Physiology and Disease
Research in my laboratory focuses on understanding the role of chemokines and lipid chemoattractants and their receptors in controlling the migratory behavior, cellular interactions and trafficking of leukocytes in vivo. Gene-targeted and transgenic reporter mouse strains have been developed to study the role of chemokines and chemoattractant receptors in the development and delivery of organ-specific innate and adaptive immune and inflammatory responses in mouse models of autoimmune, allergic, infectious and malignant diseases. The laboratory has become very interested in the role of chemokines in anti-tumor immunity and checkpoint blockade immunotherapy. System biology and in vivo multiphoton microscopy approaches are utilized to understand how multiple chemoattractant pathways are integrated in vivo for the positioning of immune cells in lymphoid and non-lymphoid tissue and for the fine control of leukocyte trafficking in vivo. Chemokines and chemoattractant receptors are interrogated in human diseases to determine chemokine systems relevant for disease pathogenesis. Finally, regulatory T cell subsets are being defined and studied for their specific roles in the control of the innate and adaptive immune response.
CIID/Rheumatology, Allergy & Immunology
149 13th Street, Rm 8304
Charlestown, MA 02129