My laboratory focuses on uncovering knowledge gaps on the interactions between the immune system and cancer and defining immunotherapies that are effective against a broad range of tumors. To do so, we study various immune cells, including cytotoxic T cells, regulatory T cells, macrophages, monocytes, neutrophils and dendritic cells.

Over the past several years, we have divided our to address both fundamental and translational research questions. In our fundamental studies, we started to address the origins of myeloid cells that accumulate in tumors and other disease sites, the capacity of tumors to hijack myeloid and other cells remotely, and the ability of some myeloid cells to mediate tumor suppressive functions. In our translational studies, we started to address how to make tumors responsive to immunotherapy by harnessing both lymphoid and myeloid cells, and how to use high-resolution imaging to uncover the pharmacokinetics and pharmacodynamics of immunotherapeutic drugs in real-time in vivo.

We collaborate with several immunology programs at Harvard Medical School, Massachusetts General Hospital, Massachusetts Institute of Technology and outside Boston.