Ramnik J. Xavier

Ramnik J. Xavier

Kurt J. Isselbacher Professor of Medicine in the Field of Gastroenterology
Ramnik J. Xavier

The Xavier Laboratory, spanning the Department of Molecular Biology at Massachusetts General Hospital and the Broad Institute, focuses on systematic characterization of genetic variants to understand the regulation of innate and adaptive immunity; initiation and resolution of tissue inflammation using single-cell and spatial transcriptomics; chemical biology to control and correct cellular disease phenotypes suggested by human genetics; molecular mechanisms that determine the roles of microbes in health and disease; and development of computational approaches to uncover patterns of human and microbial pathway activation during disease and treatment.


- Spatial transcriptomics
- Development of new technologies to study the immune system
- CRISPR base-editing and genetic screens
- Lysosomal biology
- Microbiome mining
- Computational methods


- Autoimmunity
- Genotype-to-phenotype maps
- Gut microbiome function
- Deep mechanistic studies to chemical biology
- Mucosal immunity
- Tissue metabolism


Contact Information

Massachusetts General Hospital
Center for Computational & Integrative Biology
185 Cambridge Street - Simches 7222
Boston, MA 02114
Tel: 617-643-3331
Fax: 617-643-3328

Institute Member
Broad Institute of Harvard and MIT
415 Main St., 7th Floor
Cambridge, MA 02142
p: 617-643-3331