Antigen Presentation / Processing

Gut microbiota – the trillions of bacteria, fungi, viruses, and archaea that reside in our gut – contain a dynamic arsenal of products that can protect from or contribute to disease. Diet, medication, exercise, and disease impact the composition of the...

Our laboratory is a core laboratory in the MGH Brain Tumor Immunology and Immunotherapy Program. We are focused on understanding the immune response to brain tumors in the context of the unique anatomic context of the central nervous system (CNS). ...

Over the last decade, critical discoveries in immunology and cancer biology have revealed how tumors are shaped by the immune system and how they evolve to evade it. We now know that disrupting immune checkpoints such as PD-1/PDL1 can lead to T cell...

Our group aims to understand the roles dendritic cells (DCs) play in the development and response to treatment of cancer.   DCs are a key bridge between innate and adaptive immunity, and are essential for cancer immunotherapy. These cells can also serve...

The overarching goal of the Jost lab is to define the molecular mechanisms of host-microbiome communication using a combination of systematic CRISPR technologies, physiological cell models such as organoids, and an interdisciplinary set of targeted...

My research focuses on understanding the balance between protective antitumor immunity and immunotherapy toxicities. In preclinical mouse models my lab develops novel immunotherapies designed to reduce systemic toxicities. This has involved a variety of...

Harness the tools and design principles of synthetic biology to develop novel therapies that can overcome key challenges in cancer immunotherapy

Cancer immunotherapy has shown tremendous success, however several major challenges such as the lack of ideal...

Our current research focuses on: (i) understanding the relationship of Epstein-Barr virus (EBV) with cancer immunity and immunotherapy; (ii) developing and translating cytotoxic CD4+ T cell (CD4 CTL)-based therapeutic approaches for B cell malignancies...

Inflammation is a protective response to noxious stimuli that originate from infections and injured tissues. The inflammatory process triggered in response to microbial infections is instigated by pathogen-associated molecular patterns (PAMPs), while the...

We study the molecular pathways that regulate T cell function in the tumor microenvironment, with an emphasis on developing novel mechanistic insights that lead to the development of the next generation of cancer immunotherapies. We integrate analysis of...