My laboratory seeks to understand the role and development of allergen-specific antibodies in human health and disease. Using human peripheral blood samples, our translational lab has developed several unique approaches to understanding the molecular...
The Wheeler Lab investigates how immune system interactions with the nervous system influence behavior, inflammation, and tissue plasticity in the brain and peripheral organs. Our research spans three major themes:
(1) Immune and nervous system...
Research in the laboratory is focused on the immunobiology of eosinophils. As cells of the innate immune system eosinophils are notable for their content of a single type of intracellular granule. These granules in human eosinophils contain four...
The function of many proteins is regulated by post-translational modifications. One such modification is citrullination, which converts peptidylarginine to peptidylcitrulline. This process is catalyzed by the enzymes peptidylarginine deiminases (PADs)...
Overview:
Our studies seek to leverage new tools capable of defining the dynamic nature of cell surface glycans on immune cells and microbes. This approach has provided insight into the role of glycans in immune cell development and differentiation, in...
The Pishesha Lab studies the biological complexities of antigen processing and presentation. We explore how these processes can be manipulated to modulate immunity. To that end we use engineered nanobodies and -for some applications- engineered red blood...
A major focus of our studies has been the elucidation of genetic pathways regulating tolerance and to identify human diseases resulting from defects along those pathways. We have approached this issue from the perspective of Mendelian traits associated...
Research in the Sage Lab focuses on understanding how the immune system regulates B cell responses and antibody production. Antibodies clear harmful pathogens and mediate protection elicited by vaccination. However, dysregulation of antibody responses can...
