My laboratory seeks to understand the role and development of allergen-specific antibodies in human health and disease. Using human peripheral blood samples, our translational lab has developed several unique approaches to understanding the molecular...
The Wheeler Lab investigates how immune system interactions with the nervous system influence behavior, inflammation, and tissue plasticity in the brain and peripheral organs. Our research spans three major themes:
(1) Immune and nervous system...
My research program aims to uncover how germinal centers (GCs) generate protective antibodies and to define the immunological principles that distinguish effective from ineffective immune responses. While B cells, long considered the main protagonists of...
The Tsokos laboratory studies immune cell signaling, metabolism and gene transcription in patients with systemic autoimmune diseases using state-of-the-art approaches. Our aim is to identify molecules that are central to the immunopathogenesis of the...
Overview:
Our studies seek to leverage new tools capable of defining the dynamic nature of cell surface glycans on immune cells and microbes. This approach has provided insight into the role of glycans in immune cell development and differentiation, in...
A major area of our interest is how eukaryotic cells sense and respond to stress in the form of damage to their genetic material. When cells incur DNA damage, they induce the transcription of genes involved in cell cycle arrest and repair of the damage...
Research in the Sage Lab focuses on understanding how the immune system regulates B cell responses and antibody production. Antibodies clear harmful pathogens and mediate protection elicited by vaccination. However, dysregulation of antibody responses can...
Influenza virus in humans evolves in response to pressure from immunity in the potentially susceptible population, resulting in progressive variation of viral antigenicity ("antigenic drift"). Introduction into human circulation of a new serotype from...
