My laboratory seeks to understand the role and development of allergen-specific antibodies in human health and disease. Using human peripheral blood samples, our translational lab has developed several unique approaches to understanding the molecular...
This laboratory's area of research involves studies of autoimmunity in models of experimental allergic encephalomyelitis, arthritis and diabetes in the NOD mouse. We are also investigating immune mechanisms in atherosclerosis, models of Alzheimer's...
My laboratory focuses on the molecular mechanisms of innate immunity and inflammation leading to tissue destruction. More specifically, we are investigating the attack mechanisms instrumental in targeted tissues for autoimmune destruction. Conversely, we...
Overview:
Our studies seek to leverage new tools capable of defining the dynamic nature of cell surface glycans on immune cells and microbes. This approach has provided insight into the role of glycans in immune cell development and differentiation, in...
Autoimmune Disease Deconstruction:
We have implemented a disease deconstruction pipeline using single cell and spatial technologies applied to inflamed tissues in humans to discover new cell types, cell states and pathways that mediate autoimmune disease...
Research Activities – Mathias Lichterfeld
My lab focuses on human immune responses against retroviral infections, specifically against HIV-1 and HTLV-1. In the context of HIV, my lab is specifically interested in understanding why HIV-1 reservoir cells, a...
A major focus of our studies has been the elucidation of genetic pathways regulating tolerance and to identify human diseases resulting from defects along those pathways. We have approached this issue from the perspective of Mendelian traits associated...
The major scientific interest of the Butovsky lab is to understand the biology of resident microglia and peripheral innate immunity in brain homeostasis and neurodegenerative conditions. The ultimate goal is to identify microglia- and monocyte-based...
The human intestine is exposed to a vast array of molecules from the microbiome, diet, and pathogens. The Nagashima lab focuses on three branches of research topics, all of which attempt to understand the gut immune system at the level of molecular...
Research in the Sage Lab focuses on understanding how the immune system regulates B cell responses and antibody production. Antibodies clear harmful pathogens and mediate protection elicited by vaccination. However, dysregulation of antibody responses can...
