Granulocytes

The Xavier Laboratory, spanning the Department of Molecular Biology at Massachusetts General Hospital and the Broad Institute, focuses on systematic characterization of genetic variants to understand the regulation of innate and adaptive immunity...

Our goal is to understand the role of neural-immune interactions in pain, host defense, and immunity. It is increasingly clear that microbes and immune cells release mediators that impact the health and function of the nervous system. Neurons also release...

Hemostasis and Immunity Laboratory

Our laboratory aims to understand the role of the hemostatic factors (i.e., coagulation and fibrinolytic factors) in regulating inflammation at the mucosal barrier sites. The hemostatic and inflammatory systems have...

The overall goal of my lab is to apply principles of allergic and inflammatory disease pathophysiology in humans to questions at the bench, and in turn to bring fundamental findings made at the bench back to the clinic. A dominant theme is how lipid...

Lipid signaling in immunity and inflammatory disease

My laboratory studies the biology of the bioactive lipid mediator- sphingosine 1-phosphate (S1P), a fundamental regulator of immune and vascular systems. The vertebrate immune system co-evolved with...