Our interests focus on the adaptive immune response with respect to those multiple subunit plasma membrane receptors, namely T cell receptors (TCRs) and preTCRs, that recognize peptides bound to MHC molecules (pMHCs). abTCRs specifically bind to "foreign"...
Autoimmune Disease Deconstruction:
We have implemented a disease deconstruction pipeline using single cell and spatial technologies applied to inflamed tissues in humans to discover new cell types, cell states and pathways that mediate autoimmune disease...
Our lab works in the broad fields of T cell differentiation, immunological tolerance, autoimmunity and inflammation, translating mechanistic studies on mouse models to normal and diseased humans. Studies on T cell differentiation focus on maturation and...
The Pishesha Lab studies the biological complexities of antigen processing and presentation. We explore how these processes can be manipulated to modulate immunity. To that end we use engineered nanobodies and -for some applications- engineered red blood...
Antigen-Specific Basis of Autoimmunity and Cancer
The Kohlgruber lab investigates the antigen-specific basis of human diseases and applies high-throughput molecular, genetic, and immunological assays to decipher immune system specificities and...
The human intestine is exposed to a vast array of molecules from the microbiome, diet, and pathogens. The Nagashima lab focuses on three branches of research topics, all of which attempt to understand the gut immune system at the level of molecular...
Dr. Gaurav D. Gaiha, MD, DPhil, is an Assistant Professor of Medicine at Harvard Medical School and Attending Physician in the Division of Gastroenterology at Massachusetts General Hospital (MGH). Dr. Gaiha’s lab focuses on understanding the T cell...
We study the molecular pathways that regulate T cell function in the tumor microenvironment, with an emphasis on developing novel mechanistic insights that lead to the development of the next generation of cancer immunotherapies. We integrate analysis of...
The study of histocompatibility in man and in other vertebrates led to the understanding of the mechanisms of immune recognition and to the discovery of novel molecules and cells involved in these processes, including class I and class II proteins...
