We study the molecular pathways that regulate T cell function in the tumor microenvironment, with an emphasis on developing novel mechanistic insights that lead to the development of the next generation of cancer immunotherapies. We integrate analysis of...
Immunologists in the Winau Lab are most excited about the discovery of basic mechanisms that explain how the immune system functions. Over the years, we added to the passion for basic science a strong interest in identifying targets for possible...
The study of histocompatibility in man and in other vertebrates led to the understanding of the mechanisms of immune recognition and to the discovery of novel molecules and cells involved in these processes, including class I and class II proteins...
CD4+ T cell Tolerance
CD4+ T lymphocytes comprise a principal component of the adaptive immune system. These cells recognize processed antigens derived from foreign or self proteins and integrate this information with contextual signals from the innate...
Immune therapies that engage T cells have the potential to induce long-term durable remissions of cancer. In hematologic malignancies, allogeneic hematopoietic stem cell transplant can be curative in part due to T-cell mediated anti-tumor immunity; in...
The focus of the Kwon lab is the application of new technologies to the study of immune responses against HIV at mucosal surfaces.
Mucosal surfaces represent the primary site of HIV transmission and the largest reservoir of viral replication. Despite this...
Research Interests
Our lab’s major focus is on the mechanisms by which both immune and non-hematopoietic (tissue resident) cells maintain immune quiescence in both alloimmunity and autoimmunity. Our work has been instrumental in determining the cytokine...
My laboratory focuses on the study of tissue resident T cells in humans. We isolate and study the T cells in human lung, cervix, decidua and gastrointestinal tract but we have a particular interest in T cells at home to and reside within the skin.
Our...
The Cantor lab studies the development and function of T-cell subsets. Early studies indicated that the thymus gave rise to two major lineages of T cells that recognized the MHC class II and class I molecules and were equipped to mediate distinct...
