The Sen laboratory investigates the regulation of T cell dysfunction and explores epigenetic approaches for T cell engineering. We have found that the regulatory “circuitry” of dysfunctional T cells differs remarkably from functional T cells fighting off...
Our laboratory is a core laboratory in the MGH Brain Tumor Immunology and Immunotherapy Program. We are focused on understanding the immune response to brain tumors in the context of the unique anatomic context of the central nervous system (CNS). ...
We are motivated by the widespread understanding that a productive immune response always exerts some degree of collateral damage to healthy tissue. However, our past work taught us that the amount of collateral damage tolerated by a tissue is...
Assembly and signal transduction of the T cell receptor for antigen. To examine the role of the CD3 genes in thymocyte development and in T cell function we study mice in which the CD3 genes have been eliminated by homologous recombination techniques. In...
Inflammation and Memory as Drivers of Barrier Tissue Ecology
Our goal is to understand the principles of how inflammation drives memory formation in human barrier tissues, in order to program and re-program them in disease. We are developing a training...
CD4+ T cell Tolerance
CD4+ T lymphocytes comprise a principal component of the adaptive immune system. These cells recognize processed antigens derived from foreign or self proteins and integrate this information with contextual signals from the innate...
Chemokines, resident memory effector and regulatory cells, and tissue immunity
Research in the Luster lab is varied and has historically focused on chemokines, immune cell trafficking, and resident memory effector and regulatory cells in regulating...
The focus of the Kwon lab is the application of new technologies to the study of immune responses against HIV at mucosal surfaces.
Mucosal surfaces represent the primary site of HIV transmission and the largest reservoir of viral replication. Despite this...
