Signal Transduction

A major unresolved question in immunology is how specificity of gene activation is achieved after a particular cellular stress. The human tumor necrosis factor (TNF) gene provides a unique model system in which to study cell type and inducer specific...

The Aster laboratory primarily studies Notch signaling in cancer. Ongoing projects seek to understand through use of ChIP-Seq and other comprehensive genome-wide approaches how Notch regulates the genomes of leukemia cells; how Notch activity is...