The Wheeler Lab investigates how immune system interactions with the nervous system influence behavior, inflammation, and tissue plasticity in the brain and peripheral organs. Our research spans three major themes:
(1) Immune and nervous system...
The Xavier Laboratory, spanning the Department of Molecular Biology at Massachusetts General Hospital and the Broad Institute, focuses on systematic characterization of genetic variants to understand the regulation of innate and adaptive immunity...
Our interests focus on the adaptive immune response with respect to those multiple subunit plasma membrane receptors, namely T cell receptors (TCRs) and preTCRs, that recognize peptides bound to MHC molecules (pMHCs). abTCRs specifically bind to "foreign"...
The major interests of the laboratory are the early events in human immunodeficiency virus (HIV-1) infection. Understanding and blocking these early events are critical to interrupting HIV-1 transmission and changing the course of the global AIDS pandemic...
The major focus of my laboratory is to understand the role of the NF-κB family of transcription factors in regulating innate inflammatory responses. NF-κB is generally thought of as a pro-inflammatory agent. However, work from our laboratory has...
The major scientific interest of the Butovsky lab is to understand the biology of resident microglia and peripheral innate immunity in brain homeostasis and neurodegenerative conditions. The ultimate goal is to identify microglia- and monocyte-based...
The core mission of The Majzner Laboratory is to leverage discoveries in basic immunology and cancer biology to develop and test new immunotherapeutics in children and adults with cancer. Our research program focuses on three core areas: 1) Developing...
