Description of Research:
My laboratory at Brigham and Women’s Hospital focuses on deciphering the role of stromal cells in inflammatory and fibrotic diseases. Our approach integrates single-cell transcriptomics, spatial transcriptomics, and patient...
The Wheeler Lab investigates how immune system interactions with the nervous system influence behavior, inflammation, and tissue plasticity in the brain and peripheral organs. Our research spans three major themes:
(1) Immune and nervous system...
Our goal is to understand the role of neural-immune interactions in pain, host defense, and immunity. It is increasingly clear that microbes and immune cells release mediators that impact the health and function of the nervous system. Neurons also release...
Our lab works in the broad fields of T cell differentiation, immunological tolerance, autoimmunity and inflammation, translating mechanistic studies on mouse models to normal and diseased humans. Studies on T cell differentiation focus on maturation and...
Research in the Sage Lab focuses on understanding how the immune system regulates B cell responses and antibody production. Antibodies clear harmful pathogens and mediate protection elicited by vaccination. However, dysregulation of antibody responses can...
Our group studies how cell migration organizes the communication between the innate and the adaptive immune systems. Specifically, we are interested in understanding how T lymphocytes traffic between lymphoid and non-lymphoid tissues and position...
Sensory information from the environment drives reflexive and motivated behaviors in all organisms. The types of information that are detected, how this information is coded by neural circuits, and the responses that they trigger are thus fundamental to...
The Smillie Lab uses systems approaches to understand the mechanisms of host-microbiome interactions. Our research interests are broad, spanning mucosal immunology, microbiome evolution and ecology, and tissue biology, while relying on a combination of...
Inflammation and Memory as Drivers of Barrier Tissue Ecology
Our goal is to understand the principles of how inflammation drives memory formation in human barrier tissues, in order to program and re-program them in disease. We are developing a training...
