Research in my lab focuses on elucidating mechanisms regulating tissue homeostasis and inflammation. Mammalian tissues are ecological communities of diverse cell types, including immune cells, stromal cells, neurons, endothelial cells and tissue...
The major focus of my laboratory is to understand the role of the NF-κB family of transcription factors in regulating innate inflammatory responses. NF-κB is generally thought of as a pro-inflammatory agent. However, work from our laboratory has...
The Pishesha Lab studies the biological complexities of antigen processing and presentation. We explore how these processes can be manipulated to modulate immunity. To that end we use engineered nanobodies and -for some applications- engineered red blood...
Antigen-Specific Basis of Autoimmunity and Cancer
The Kohlgruber lab investigates the antigen-specific basis of human diseases and applies high-throughput molecular, genetic, and immunological assays to decipher immune system specificities and...
A major focus of our studies has been the elucidation of genetic pathways regulating tolerance and to identify human diseases resulting from defects along those pathways. We have approached this issue from the perspective of Mendelian traits associated...
The broad focus of the Alt lab is the elucidation of mechanisms that generate antigen receptor diversity in the Immune system and mechanisms that maintain genomic stability in mammalian cells. Over the past decade we have developed remarkably sensitive...
Sensory information from the environment drives reflexive and motivated behaviors in all organisms. The types of information that are detected, how this information is coded by neural circuits, and the responses that they trigger are thus fundamental to...
