Brigham & Women's Hospital

Description of Research: 

My laboratory at Brigham and Women’s Hospital focuses on deciphering the role of stromal cells in inflammatory and fibrotic diseases.  Our approach integrates single-cell transcriptomics, spatial transcriptomics, and patient...

This laboratory's area of research involves studies of autoimmunity in models of experimental allergic encephalomyelitis, arthritis and diabetes in the NOD mouse. We are also investigating immune mechanisms in atherosclerosis, models of Alzheimer's...

My laboratory focuses on the molecular mechanisms of innate immunity and inflammation leading to tissue destruction. More specifically, we are investigating the attack mechanisms instrumental in targeted tissues for autoimmune destruction. Conversely, we...

The function of many proteins is regulated by post-translational modifications. One such modification is citrullination, which converts peptidylarginine to peptidylcitrulline. This process is catalyzed by the enzymes peptidylarginine deiminases (PADs)...

Overview:

Our studies seek to leverage new tools capable of defining the dynamic nature of cell surface glycans on immune cells and microbes. This approach has provided insight into the role of glycans in immune cell development and differentiation, in...

Autoimmune Disease Deconstruction:

We have implemented a disease deconstruction pipeline using single cell and spatial technologies applied to inflamed tissues in humans to discover new cell types, cell states and pathways that mediate autoimmune disease...

The major scientific interest of the Butovsky lab is to understand the biology of resident microglia and peripheral innate immunity in brain homeostasis and neurodegenerative conditions. The ultimate goal is to identify microglia- and monocyte-based...

Research in the Sage Lab focuses on understanding how the immune system regulates B cell responses and antibody production. Antibodies clear harmful pathogens and mediate protection elicited by vaccination. However, dysregulation of antibody responses can...

The overall goal of my lab is to apply principles of allergic and inflammatory disease pathophysiology in humans to questions at the bench, and in turn to bring fundamental findings made at the bench back to the clinic. A dominant theme is how lipid...

Symbiotic microbiota residing on the body surface (gut lumen, skin and other areas) easily outnumbers our own cells and dwarfs our genome by hundred folds with their metagenome.  Large-scale research projects such as Human Microbiome Project have...