Our laboratory is focused on dissecting the mechanisms of immune escape and tumor-immune crosstalk in pancreatic cancer and other malignancies, with the overarching goal of rapidly using these insights to guide therapeutic advances for cancer patients...
Our interests focus on the adaptive immune response with respect to those multiple subunit plasma membrane receptors, namely T cell receptors (TCRs) and preTCRs, that recognize peptides bound to MHC molecules (pMHCs). abTCRs specifically bind to "foreign"...
The major interests of the laboratory are the early events in human immunodeficiency virus (HIV-1) infection. Understanding and blocking these early events are critical to interrupting HIV-1 transmission and changing the course of the global AIDS pandemic...
Our laboratory focuses on the engineering of human monoclonal antibodies for their use in discovery research and as drugs for the treatment of human diseases. We are working in two broad disease areas: emerging infectious diseases and cancer. We have...
The core mission of The Majzner Laboratory is to leverage discoveries in basic immunology and cancer biology to develop and test new immunotherapeutics in children and adults with cancer. Our research program focuses on three core areas: 1) Developing...
Rapid advances in gene engineering make the previously unimaginable rapidly accessible. The Smith Lab for Genetic and Cellular Engineering uses synthetic biology to address our missions of: (1) answering pressing questions around the biology of...
Research focus of my lab is to use novel synthetic biology approaches to manipulate conventional and memory-like Natural Killer (NK) cells to enhance their anti-tumor function. Using advanced CRISPR and non-CRISPR based gene editing approaches we are...
We are interested in elucidating the mechanisms controlling immune privilege of tissue-resident stem cells and cancer stem cells.
Stem cells are crucial for tissue homeostasis and regeneration and, as a consequence, some have evolved mechanisms to cloak...
