My research program aims to uncover how germinal centers (GCs) generate protective antibodies and to define the immunological principles that distinguish effective from ineffective immune responses. While B cells, long considered the main protagonists of...
A major area of our interest is how eukaryotic cells sense and respond to stress in the form of damage to their genetic material. When cells incur DNA damage, they induce the transcription of genes involved in cell cycle arrest and repair of the damage...
Our goal is to understand the role of neural-immune interactions in pain, host defense, and immunity. It is increasingly clear that microbes and immune cells release mediators that impact the health and function of the nervous system. Neurons also release...
Our lab works in the broad fields of T cell differentiation, immunological tolerance, autoimmunity and inflammation, translating mechanistic studies on mouse models to normal and diseased humans. Studies on T cell differentiation focus on maturation and...
Our lab has several interests, generally organized around the genetic and genomic control of immunological tolerance and autoimmune diseases. We study how T cells differentiate into different lineages in the thymus, and how the Aire transcription factor...
Influenza virus in humans evolves in response to pressure from immunity in the potentially susceptible population, resulting in progressive variation of viral antigenicity ("antigenic drift"). Introduction into human circulation of a new serotype from...
We are motivated by the widespread understanding that a productive immune response always exerts some degree of collateral damage to healthy tissue. However, our past work taught us that the amount of collateral damage tolerated by a tissue is...
The overarching goal of the Jost lab is to define the molecular mechanisms of host-microbiome communication using a combination of systematic CRISPR technologies, physiological cell models such as organoids, and an interdisciplinary set of targeted...
