Topics and Potential Rotation Projects:
1) Innate and Adaptive Immune Mechanisms for Regulating Mucosal Inflammation; 2) Characterizing and Manipulating Regulatory T cell Circuits In vivo; 3) Leukocyte and Epithelial Cell Signaling; 4) Regulation of the...
The Scadden laboratory focuses on blood: how it is made, how it is corrupted in malignancy and how understanding it can lead to new therapies. We think of bone marrow as the perfect system to examine tissue systems biology. We combine in vivo imaging...
The vertebrate immune system is capable of specifically recognizing and responding to an enormous number of antigens. The interaction with antigen is mediated by the immunoglobulin (Ig) and T cell receptor (TCR) molecules expressed by B and T lymphocytes...
One of the major players in innate immune system is neutrophil which is the most abundant cell type among circulating white blood cells and constitutes the first line of host defense against invading bacteria and other pathogens. In response to...
The Lieberman laboratory studies the innate and adaptive immune response to infection and cancer. They seek to understand how cytotoxic T lymphocytes and NK cells provide immune protection in some conditions and fail to function or cause immune pathology...
My laboratory studies the cell and molecular biology of polarized epithelial cells lining mucosal surfaces. The projects focus on how barrier epithelial cells interact with the lumenal and sub-epithelial microenvironment, and on the biology of bacterial...
My laboratory has long been interested in the interactions of microbes, both commensals and pathogens, with the immune system. Our overall major research focus has been on bacterial carbohydrates. In studies innovatively integrating structural...
Mucosal Immunobiology
The mucosal barriers of the body facilitate the arduous task of promoting symbiosis with the resident microbiota while simultaneously preventing microbial invasion and pathogenic inflammation. We aim to uncover not only how tissue...
Repair of Double stranded DNA breaks-pathway choices and more
Double stranded DNA breaks (DSBs) are critical for cell health as a single unrepaired DSB is sufficient for inducing apoptosis. Two major mechanistically distinct pathways, homologous...
