Influenza virus in humans evolves in response to pressure from immunity in the potentially susceptible population, resulting in progressive variation of viral antigenicity ("antigenic drift"). Introduction into human circulation of a new serotype from...
We are motivated by the widespread understanding that a productive immune response always exerts some degree of collateral damage to healthy tissue. However, our past work taught us that the amount of collateral damage tolerated by a tissue is...
The Smillie Lab uses systems approaches to understand the mechanisms of host-microbiome interactions. Our research interests are broad, spanning mucosal immunology, microbiome evolution and ecology, and tissue biology, while relying on a combination of...
Harness the tools and design principles of synthetic biology to develop novel therapies that can overcome key challenges in cancer immunotherapy
Cancer immunotherapy has shown tremendous success, however several major challenges such as the lack of ideal...
Our current research focuses on: (i) understanding the relationship of Epstein-Barr virus (EBV) with cancer immunity and immunotherapy; (ii) developing and translating cytotoxic CD4+ T cell (CD4 CTL)-based therapeutic approaches for B cell malignancies...
Immunologists in the Winau Lab are most excited about the discovery of basic mechanisms that explain how the immune system functions. Over the years, we added to the passion for basic science a strong interest in identifying targets for possible...
Chemokines, resident memory effector and regulatory cells, and tissue immunity
Research in the Luster lab is varied and has historically focused on chemokines, immune cell trafficking, and resident memory effector and regulatory cells in regulating...
