The laboratory focuses on the developmental biology of hematopoiesis and cancer. We have collected over 30 mutants affecting the hematopoietic system. Some of the mutants represent excellent animal models of human disease. We also have undertaken...
We are studying cancer genetics using the zebrafish animal model as an in vivo system, in combination with RNAi knockdown of critical genes in human tumor cell lines, to dissect developmental pathways subverted in human leukemias and solid tumors. The...
My laboratory studies the cell and molecular biology of polarized epithelial cells lining mucosal surfaces. The projects focus on how barrier epithelial cells interact with the lumenal and sub-epithelial microenvironment, and on the biology of bacterial...
