Mast Cells are long-lived tissue resident immune cells that play a pathogenic role in human type 2 allergic inflammatory diseases. Mast cells arise from circulating progenitor cells that mature in peripheral tissues and take on different phenotypes based...
Commensal intestinal bacteria participate in digestion of the host diet, provide essential amino acids and vitamins, and secrete metabolites that control many aspects of host intestinal function. In contrast, pathogens disrupt intestinal function. The...
The major interest of the Sharpe laboratory is to study functions of T cell costimulatory pathways and their immunoregulatory roles in controlling the balance between T cell activation and tolerance. Costimulation is of therapeutic interest because...
The overarching goal of the Jost lab is to define the molecular mechanisms of host-microbiome communication using a combination of systematic CRISPR technologies, physiological cell models such as organoids, and an interdisciplinary set of targeted...
My research focuses on understanding the balance between protective antitumor immunity and immunotherapy toxicities. In preclinical mouse models my lab develops novel immunotherapies designed to reduce systemic toxicities. This has involved a variety of...
Harness the tools and design principles of synthetic biology to develop novel therapies that can overcome key challenges in cancer immunotherapy
Cancer immunotherapy has shown tremendous success, however several major challenges such as the lack of ideal...
The laboratory focuses on the developmental biology of hematopoiesis and cancer. We have collected over 30 mutants affecting the hematopoietic system. Some of the mutants represent excellent animal models of human disease. We also have undertaken...
Inflammation is a protective response to noxious stimuli that originate from infections and injured tissues. The inflammatory process triggered in response to microbial infections is instigated by pathogen-associated molecular patterns (PAMPs), while the...
We study the molecular pathways that regulate T cell function in the tumor microenvironment, with an emphasis on developing novel mechanistic insights that lead to the development of the next generation of cancer immunotherapies. We integrate analysis of...
