Our laboratory investigates the role of the immune system in modulating the early stages of cancer development in order to harness its anti-tumor properties to combat cancer. To date, several cancer immunotherapeutic drugs have been developed with proven...
Somatic cell nuclear transfer (SCNT) may be used to clone mice from lymphocytes of defined specificity. By harvesting as few as 200 primary lymphocytes from animals that are at the peak of an immune response, and by transfer of the nucleus from such...
The Ebert laboratory focuses on the molecular basis and treatment of hematologic malignancies, with a particular focus on myelodysplastic syndromes (MDS). In large-scale genetic analyses of patient samples, the lab has identified somatic mutations that...
The Geha laboratory focuses on the molecular basis and mechanisms of (1) primary immune deficiency diseases and (2) atopic dermatitis.
Genetics and molecular basis of novel primary immunodeficiencies:
Primary immunodeficiencies (PID) are genetic...
In many developmental systems, nuclear regulators have been implicated in coupling key events in gene expression with specific cell fate and lineage decisions. Focusing on this topic in the hemo-lymphoid system,we identified and shown in a series of...
My research focuses on understanding mechanisms of tumor progression from early precursor conditions such as monoclonal gammopathy of undetermined significance (MGUS) and smoldering myeloma (SMM) to symptomatic Multiple Myeloma (MM). I specifically focus...
A major unresolved question in immunology is how specificity of gene activation is achieved after a particular cellular stress. The human tumor necrosis factor (TNF) gene provides a unique model system in which to study cell type and inducer specific...
Lipid signaling in immunity and inflammatory disease
My laboratory studies the biology of the bioactive lipid mediator- sphingosine 1-phosphate (S1P), a fundamental regulator of immune and vascular systems. The vertebrate immune system co-evolved with...
Immune cell modulation is an attractive strategy for the treatment of inflammatory conditions. Inflammation is critical to protecting us from dangers within (e.g. cancer) and without (e.g. microbes). But inflammation also drives much human pathology and...
Elucidating the Molecular Principles of Self vs Non-self RNA Discrimination by the Immune System
Correct discrimination of “self” vs “non-self” nucleic acids by the innate immune system is essential for host defense against viral infection. A failure to...
