Mast Cells are long-lived tissue resident immune cells that play a pathogenic role in human type 2 allergic inflammatory diseases. Mast cells arise from circulating progenitor cells that mature in peripheral tissues and take on different phenotypes based...
The major interest of the Sharpe laboratory is to study functions of T cell costimulatory pathways and their immunoregulatory roles in controlling the balance between T cell activation and tolerance. Costimulation is of therapeutic interest because...
The B cell receptor (BCR) is essential for survival of mature B cells and its specificity dictates the cells' fate from early development through final differentiation into an effector or memory cell. For example, immature B cells bearing a self-reactive...
The Sen laboratory investigates the regulation of T cell dysfunction and explores epigenetic approaches for T cell engineering. We have found that the regulatory “circuitry” of dysfunctional T cells differs remarkably from functional T cells fighting off...
Research in the Anderson Laboratory focuses on understanding the pathways and mechanisms that regulate the T cell response in chronic disease, particularly in cancer. Specific areas of investigation are examination of the role of co-inhibitory/immune...
Immune therapies that engage T cells have the potential to induce long-term durable remissions of cancer. In hematologic malignancies, allogeneic hematopoietic stem cell transplant can be curative in part due to T-cell mediated anti-tumor immunity; in...
Our group studies how cell migration organizes the communication between the innate and the adaptive immune systems. Specifically, we are interested in understanding how T lymphocytes traffic between lymphoid and non-lymphoid tissues and position...
By the time we see patients in the clinic, pathology is usually established, and the flames of inflammation are already burning. What keeps inflammation going, and can we do anything about it? The central theme of our laboratory is to understand the...
The Lieberman laboratory studies the innate and adaptive immune response to infection and cancer. They seek to understand how cytotoxic T lymphocytes and NK cells provide immune protection in some conditions and fail to function or cause immune pathology...
Research in my lab focuses on elucidating mechanisms regulating tissue homeostasis and inflammation. Mammalian tissues are ecological communities of diverse cell types, including immune cells, stromal cells, neurons, endothelial cells and tissue...
Our lab works in the broad fields of T cell differentiation, immunological tolerance, autoimmunity and inflammation, translating mechanistic studies on mouse models to normal and diseased humans. Studies on T cell differentiation focus on maturation and...
