Description of Research:
My laboratory at Brigham and Women’s Hospital focuses on deciphering the role of stromal cells in inflammatory and fibrotic diseases. Our approach integrates single-cell transcriptomics, spatial transcriptomics, and patient...
Inflammation and Memory as Drivers of Barrier Tissue Ecology
Our goal is to understand the principles of how inflammation drives memory formation in human barrier tissues, in order to program and re-program them in disease. We are developing a training...
Our lab works in the broad fields of T cell differentiation, immunological tolerance, autoimmunity and inflammation, translating mechanistic studies on mouse models to normal and diseased humans. Studies on T cell differentiation focus on maturation and...
Research Interest and/or Dissertation Project:
Stromal-immune cell interactions, tissue repair, type 2 immunity, lung biology, imaging techniques
Undergraduate Institution:
Wellesley College
Hometown:
Houston, TX
Other Places I have lived:
Atlanta, GA, Jakarta...
Somatic cell nuclear transfer (SCNT) may be used to clone mice from lymphocytes of defined specificity. By harvesting as few as 200 primary lymphocytes from animals that are at the peak of an immune response, and by transfer of the nucleus from such...
Research in my lab focuses on elucidating mechanisms regulating tissue homeostasis and inflammation. Mammalian tissues are ecological communities of diverse cell types, including immune cells, stromal cells, neurons, endothelial cells and tissue...
My research focuses on understanding mechanisms of tumor progression from early precursor conditions such as monoclonal gammopathy of undetermined significance (MGUS) and smoldering myeloma (SMM) to symptomatic Multiple Myeloma (MM). I specifically focus...
Autoimmune Disease Deconstruction:
We have implemented a disease deconstruction pipeline using single cell and spatial technologies applied to inflamed tissues in humans to discover new cell types, cell states and pathways that mediate autoimmune disease...
The Smillie Lab uses systems approaches to understand the mechanisms of host-microbiome interactions. Our research interests are broad, spanning mucosal immunology, microbiome evolution and ecology, and tissue biology, while relying on a combination of...
