Our laboratory is focused on dissecting the mechanisms of immune escape and tumor-immune crosstalk in pancreatic cancer and other malignancies, with the overarching goal of rapidly using these insights to guide therapeutic advances for cancer patients...
Description of Research:
My laboratory at Brigham and Women’s Hospital focuses on deciphering the role of stromal cells in inflammatory and fibrotic diseases. Our approach integrates single-cell transcriptomics, spatial transcriptomics, and patient...
The Penaloza-MacMaster Laboratory
Viral pandemics remain an enduring threat to humanity. The Penaloza-MacMaster Laboratory focuses on developing novel strategies to prevent and treat viral infections by integrating fundamental immunology with translational...
The Wheeler Lab investigates how immune system interactions with the nervous system influence behavior, inflammation, and tissue plasticity in the brain and peripheral organs. Our research spans three major themes:
(1) Immune and nervous system...
My research program aims to uncover how germinal centers (GCs) generate protective antibodies and to define the immunological principles that distinguish effective from ineffective immune responses. While B cells, long considered the main protagonists of...
The Tsokos laboratory studies immune cell signaling, metabolism and gene transcription in patients with systemic autoimmune diseases using state-of-the-art approaches. Our aim is to identify molecules that are central to the immunopathogenesis of the...
The Xavier Laboratory, spanning the Department of Molecular Biology at Massachusetts General Hospital and the Broad Institute, focuses on systematic characterization of genetic variants to understand the regulation of innate and adaptive immunity...
Research in the laboratory is focused on the immunobiology of eosinophils. As cells of the innate immune system eosinophils are notable for their content of a single type of intracellular granule. These granules in human eosinophils contain four...
This laboratory's area of research involves studies of autoimmunity in models of experimental allergic encephalomyelitis, arthritis and diabetes in the NOD mouse. We are also investigating immune mechanisms in atherosclerosis, models of Alzheimer's...
Our interests focus on the adaptive immune response with respect to those multiple subunit plasma membrane receptors, namely T cell receptors (TCRs) and preTCRs, that recognize peptides bound to MHC molecules (pMHCs). abTCRs specifically bind to "foreign"...
