Gut microbiota – the trillions of bacteria, fungi, viruses, and archaea that reside in our gut – contain a dynamic arsenal of products that can protect from or contribute to disease. Diet, medication, exercise, and disease impact the composition of the...
Our laboratory is a core laboratory in the MGH Brain Tumor Immunology and Immunotherapy Program. We are focused on understanding the immune response to brain tumors in the context of the unique anatomic context of the central nervous system (CNS). ...
The Jan laboratory primarily focuses on the development of clinically suitable synthetic biology platforms in order to advance next-generation cellular immunotherapies. We contribute to these goals by harnessing elegant protein degradation cellular...
My research focuses on understanding the balance between protective antitumor immunity and immunotherapy toxicities. In preclinical mouse models my lab develops novel immunotherapies designed to reduce systemic toxicities. This has involved a variety of...
Harness the tools and design principles of synthetic biology to develop novel therapies that can overcome key challenges in cancer immunotherapy
Cancer immunotherapy has shown tremendous success, however several major challenges such as the lack of ideal...
We study the molecular pathways that regulate T cell function in the tumor microenvironment, with an emphasis on developing novel mechanistic insights that lead to the development of the next generation of cancer immunotherapies. We integrate analysis of...
Immunologists in the Winau Lab are most excited about the discovery of basic mechanisms that explain how the immune system functions. Over the years, we added to the passion for basic science a strong interest in identifying targets for possible...
The study of histocompatibility in man and in other vertebrates led to the understanding of the mechanisms of immune recognition and to the discovery of novel molecules and cells involved in these processes, including class I and class II proteins...
Immune therapies that engage T cells have the potential to induce long-term durable remissions of cancer. In hematologic malignancies, allogeneic hematopoietic stem cell transplant can be curative in part due to T-cell mediated anti-tumor immunity; in...
