Description of Research:
My laboratory at Brigham and Women’s Hospital focuses on deciphering the role of stromal cells in inflammatory and fibrotic diseases. Our approach integrates single-cell transcriptomics, spatial transcriptomics, and patient...
The Wheeler Lab investigates how immune system interactions with the nervous system influence behavior, inflammation, and tissue plasticity in the brain and peripheral organs. Our research spans three major themes:
(1) Immune and nervous system...
The Tsokos laboratory studies immune cell signaling, metabolism and gene transcription in patients with systemic autoimmune diseases using state-of-the-art approaches. Our aim is to identify molecules that are central to the immunopathogenesis of the...
The Xavier Laboratory, spanning the Department of Molecular Biology at Massachusetts General Hospital and the Broad Institute, focuses on systematic characterization of genetic variants to understand the regulation of innate and adaptive immunity...
This laboratory's area of research involves studies of autoimmunity in models of experimental allergic encephalomyelitis, arthritis and diabetes in the NOD mouse. We are also investigating immune mechanisms in atherosclerosis, models of Alzheimer's...
My laboratory focuses on the molecular mechanisms of innate immunity and inflammation leading to tissue destruction. More specifically, we are investigating the attack mechanisms instrumental in targeted tissues for autoimmune destruction. Conversely, we...
The function of many proteins is regulated by post-translational modifications. One such modification is citrullination, which converts peptidylarginine to peptidylcitrulline. This process is catalyzed by the enzymes peptidylarginine deiminases (PADs)...
Overview:
Our studies seek to leverage new tools capable of defining the dynamic nature of cell surface glycans on immune cells and microbes. This approach has provided insight into the role of glycans in immune cell development and differentiation, in...
The major focus of my laboratory is to understand the role of the NF-κB family of transcription factors in regulating innate inflammatory responses. NF-κB is generally thought of as a pro-inflammatory agent. However, work from our laboratory has...
A major area of our interest is how eukaryotic cells sense and respond to stress in the form of damage to their genetic material. When cells incur DNA damage, they induce the transcription of genes involved in cell cycle arrest and repair of the damage...
