In the Kuchroo laboratory, our overarching goal is elucidating the mechanisms that regulate immune functions in health, aging and different disease contexts. We focus on the functions of different CD4+ T helper subsets, and the role of costimulatory...
The Hacohen lab consists of immunologists, geneticists, biochemists, technologists, physicians and computational biologists working together to develop new and unbiased technologies and strategies to understand basic immune processes and immune-mediated...
Rapid advances in gene engineering make the previously unimaginable rapidly accessible. The Smith Lab for Genetic and Cellular Engineering uses synthetic biology to address our missions of: (1) answering pressing questions around the biology of...
Dr. Gravallese is the Theodore Bevier Bayles Professor of Medicine and Chief of the Division of Rheumatology, Inflammation and Immunity at Brigham and Women’s Hospital. The Gravallese laboratory is devoted to understanding the pathogenesis of systemic...
The Smillie Lab uses systems approaches to understand the mechanisms of host-microbiome interactions. Our research interests are broad, spanning mucosal immunology, microbiome evolution and ecology, and tissue biology, while relying on a combination of...
The major interest of the Sharpe laboratory is to study functions of T cell costimulatory pathways and their immunoregulatory roles in controlling the balance between T cell activation and tolerance. Costimulation is of therapeutic interest because...
My research focuses on understanding the balance between protective antitumor immunity and immunotherapy toxicities. In preclinical mouse models my lab develops novel immunotherapies designed to reduce systemic toxicities. This has involved a variety of...
