Chemokines

The Wheeler Lab investigates how immune system interactions with the nervous system influence behavior, inflammation, and tissue plasticity in the brain and peripheral organs. Our research spans three major themes:

(1) Immune and nervous system...

The broad interest of the WAGERS LAB is to identify and analyze tissue-specific stem cell populations in adult animals. This work focuses on understanding the factors controlling the migration and expansion of bone marrow-derived and blood-forming...

My laboratory focuses on the molecular mechanisms of innate immunity and inflammation leading to tissue destruction. More specifically, we are investigating the attack mechanisms instrumental in targeted tissues for autoimmune destruction. Conversely, we...

Our group studies how cell migration organizes the communication between the innate and the adaptive immune systems. Specifically, we are interested in understanding how T lymphocytes traffic between lymphoid and non-lymphoid tissues and position...

The core mission of The Majzner Laboratory is to leverage discoveries in basic immunology and cancer biology to develop and test new immunotherapeutics in children and adults with cancer. Our research program focuses on three core areas: 1) Developing...

The Bod Lab focuses on deciphering the landscape of phenotypic and functional B cell states in inflammatory diseases, in particular cancer. We are interested in exploring which B cell subset is favorable or detrimental for cancer progression, and by...

Rapid advances in gene engineering make the previously unimaginable rapidly accessible. The Smith Lab for Genetic and Cellular Engineering uses synthetic biology to address our missions of: (1) answering pressing questions around the biology of...

The major goal of the Guerriero lab is to accelerate breast cancer immunotherapy by harnessing tumor associated macrophages. To date, immunotherapy has largely focused on recruiting and activating anti-tumor T cells, which has shown tremendous responses...

I oversee the basic and translational research work of a team of lead investigators, postdoctoral fellows and other trainees who I mentor at the Vaccine and Immunotherapy Center (VIC) at Massachusetts General Hospital and Harvard Medical School. The goal...

Immune cells play important roles in retinal vascular development/remodeling/repair and degeneration. Immune dysregulation during these processes in the eye leads to diseases such as retinopathy of prematurity and age-related macular degeneration. Our...