Sensory information from the environment drives reflexive and motivated behaviors in all organisms. The types of information that are detected, how this information is coded by neural circuits, and the responses that they trigger are thus fundamental to...
The Sen laboratory investigates the regulation of T cell dysfunction and explores epigenetic approaches for T cell engineering. We have found that the regulatory “circuitry” of dysfunctional T cells differs remarkably from functional T cells fighting off...
Symbiotic microbiota residing on the body surface (gut lumen, skin and other areas) easily outnumbers our own cells and dwarfs our genome by hundred folds with their metagenome. Large-scale research projects such as Human Microbiome Project have...
Research focus of my lab is to use novel synthetic biology approaches to manipulate conventional and memory-like Natural Killer (NK) cells to enhance their anti-tumor function. Using advanced CRISPR and non-CRISPR based gene editing approaches we are...
The Hemberg group specializes in computational genomics, developing innovative algorithms and analytical tools for high-throughput biological datasets while collaborating with experimental teams to drive discovery. Our research operates on two...
Gut microbiota – the trillions of bacteria, fungi, viruses, and archaea that reside in our gut – contain a dynamic arsenal of products that can protect from or contribute to disease. Diet, medication, exercise, and disease impact the composition of the...
We are motivated by the widespread understanding that a productive immune response always exerts some degree of collateral damage to healthy tissue. However, our past work taught us that the amount of collateral damage tolerated by a tissue is...
