Immune cells play important roles in retinal vascular development/remodeling/repair and degeneration. Immune dysregulation during these processes in the eye leads to diseases such as retinopathy of prematurity and age-related macular degeneration. Our...
The Garrett Lab is interested in defining the dynamic interactions between the mucosal immune system and gut microbiota. Our experimental questions are grounded in understanding how interactions between intestinal microbial communities and the immune...
Our group studies how cell migration organizes the communication between the innate and the adaptive immune systems. Specifically, we are interested in understanding how T lymphocytes traffic between lymphoid and non-lymphoid tissues and position...
A major area of our interest is how eukaryotic cells sense and respond to stress in the form of damage to their genetic material. When cells incur DNA damage, they induce the transcription of genes involved in cell cycle arrest and repair of the damage...
Influenza virus in humans evolves in response to pressure from immunity in the potentially susceptible population, resulting in progressive variation of viral antigenicity ("antigenic drift"). Introduction into human circulation of a new serotype from...
Our laboratory investigates the role of the immune system in modulating the early stages of cancer development in order to harness its anti-tumor properties to combat cancer. To date, several cancer immunotherapeutic drugs have been developed with proven...
Overview:
Our studies seek to leverage new tools capable of defining the dynamic nature of cell surface glycans on immune cells and microbes. This approach has provided insight into the role of glycans in immune cell development and differentiation, in...
Mucosal Immunobiology
The mucosal barriers of the body facilitate the arduous task of promoting symbiosis with the resident microbiota while simultaneously preventing microbial invasion and pathogenic inflammation. We aim to uncover not only how tissue...
