Our laboratory is focused on dissecting the mechanisms of immune escape and tumor-immune crosstalk in pancreatic cancer and other malignancies, with the overarching goal of rapidly using these insights to guide therapeutic advances for cancer patients...
My laboratory seeks to understand the role and development of allergen-specific antibodies in human health and disease. Using human peripheral blood samples, our translational lab has developed several unique approaches to understanding the molecular...
The Penaloza-MacMaster Laboratory
Viral pandemics remain an enduring threat to humanity. The Penaloza-MacMaster Laboratory focuses on developing novel strategies to prevent and treat viral infections by integrating fundamental immunology with translational...
The Wheeler Lab investigates how immune system interactions with the nervous system influence behavior, inflammation, and tissue plasticity in the brain and peripheral organs. Our research spans three major themes:
(1) Immune and nervous system...
Our interests focus on the adaptive immune response with respect to those multiple subunit plasma membrane receptors, namely T cell receptors (TCRs) and preTCRs, that recognize peptides bound to MHC molecules (pMHCs). abTCRs specifically bind to "foreign"...
Research Activities – Mathias Lichterfeld
My lab focuses on human immune responses against retroviral infections, specifically against HIV-1 and HTLV-1. In the context of HIV, my lab is specifically interested in understanding why HIV-1 reservoir cells, a...
The Pishesha Lab studies the biological complexities of antigen processing and presentation. We explore how these processes can be manipulated to modulate immunity. To that end we use engineered nanobodies and -for some applications- engineered red blood...
The major scientific interest of the Butovsky lab is to understand the biology of resident microglia and peripheral innate immunity in brain homeostasis and neurodegenerative conditions. The ultimate goal is to identify microglia- and monocyte-based...
Research in the Sage Lab focuses on understanding how the immune system regulates B cell responses and antibody production. Antibodies clear harmful pathogens and mediate protection elicited by vaccination. However, dysregulation of antibody responses can...
The core mission of The Majzner Laboratory is to leverage discoveries in basic immunology and cancer biology to develop and test new immunotherapeutics in children and adults with cancer. Our research program focuses on three core areas: 1) Developing...
