Immunotherapy

The Bod Lab focuses on deciphering the landscape of phenotypic and functional B cell states in inflammatory diseases, in particular cancer. We are interested in exploring which B cell subset is favorable or detrimental for cancer progression, and by...

 

Dr. Gaurav D. Gaiha, MD, DPhil, is an Assistant Professor of Medicine at Harvard Medical School and Attending Physician in the Division of Gastroenterology at Massachusetts General Hospital (MGH). Dr. Gaiha’s lab focuses on understanding the T cell...

Rapid advances in gene engineering make the previously unimaginable rapidly accessible. The Smith Lab for Genetic and Cellular Engineering uses synthetic biology to address our missions of: (1) answering pressing questions around the biology of...

The Sen laboratory investigates the regulation of T cell dysfunction and explores epigenetic approaches for T cell engineering. We have found that the regulatory “circuitry” of dysfunctional T cells differs remarkably from functional T cells fighting off...

The major goal of the Guerriero lab is to accelerate breast cancer immunotherapy by harnessing tumor associated macrophages. To date, immunotherapy has largely focused on recruiting and activating anti-tumor T cells, which has shown tremendous responses...

Research focus of my lab is to use novel synthetic biology approaches to manipulate conventional and memory-like Natural Killer (NK) cells to enhance their anti-tumor function. Using advanced CRISPR and non-CRISPR based gene editing approaches we are...

The Hemberg group specializes in computational genomics, developing innovative algorithms and analytical tools for high-throughput biological datasets while collaborating with experimental teams to drive discovery. Our research operates on two...

Gut microbiota – the trillions of bacteria, fungi, viruses, and archaea that reside in our gut – contain a dynamic arsenal of products that can protect from or contribute to disease. Diet, medication, exercise, and disease impact the composition of the...

Our laboratory is a core laboratory in the MGH Brain Tumor Immunology and Immunotherapy Program. We are focused on understanding the immune response to brain tumors in the context of the unique anatomic context of the central nervous system (CNS). ...

The Griffin Lab applies emerging functional genomic, sequencing, and immunologic tools to define fundamental mechanisms of immune regulation in tumors. We then seek to translate these insights into better immunotherapies for patients with cancer. A major...