Our group studies how cell migration organizes the communication between the innate and the adaptive immune systems. Specifically, we are interested in understanding how T lymphocytes traffic between lymphoid and non-lymphoid tissues and position...
Research focus of my lab is to use novel synthetic biology approaches to manipulate conventional and memory-like Natural Killer (NK) cells to enhance their anti-tumor function. Using advanced CRISPR and non-CRISPR based gene editing approaches we are...
My research focuses on understanding the balance between protective antitumor immunity and immunotherapy toxicities. In preclinical mouse models my lab develops novel immunotherapies designed to reduce systemic toxicities. This has involved a variety of...
Harness the tools and design principles of synthetic biology to develop novel therapies that can overcome key challenges in cancer immunotherapy
Cancer immunotherapy has shown tremendous success, however several major challenges such as the lack of ideal...
Immunologists in the Winau Lab are most excited about the discovery of basic mechanisms that explain how the immune system functions. Over the years, we added to the passion for basic science a strong interest in identifying targets for possible...
Innate and neuro-immune control of allergic immunity
The innate immune system plays a central role in adaptive immune initiation by sensing microbial invasion and environmental stress and using that information to promote specific adaptive immune...
The Rao lab is focused on modulating pathologic lymphocyte functions to treat human autoimmune diseases. T cells are central regulators in multiple autoimmune diseases, yet defining their key functions in different diseases has been challenging. Our...
Chemokines, resident memory effector and regulatory cells, and tissue immunity
Research in the Luster lab is varied and has historically focused on chemokines, immune cell trafficking, and resident memory effector and regulatory cells in regulating...
Lipid signaling in immunity and inflammatory disease
My laboratory studies the biology of the bioactive lipid mediator- sphingosine 1-phosphate (S1P), a fundamental regulator of immune and vascular systems. The vertebrate immune system co-evolved with...
