Neuro-Immunology

We seek to develop and apply technologies (particularly revolving around high-dimensional tissue imaging) to address questions related to host-disease interactions in their native tissue context. By combining these methodologies with a systems approach...

The Hemberg group specializes in computational genomics, developing innovative algorithms and analytical tools for high-throughput biological datasets while collaborating with experimental teams to drive discovery. Our research operates on two...

I oversee the basic and translational research work of a team of lead investigators, postdoctoral fellows and other trainees who I mentor at the Vaccine and Immunotherapy Center (VIC) at Massachusetts General Hospital and Harvard Medical School. The goal...

The Smillie Lab uses systems approaches to understand the mechanisms of host-microbiome interactions. Our research interests are broad, spanning mucosal immunology, microbiome evolution and ecology, and tissue biology, while relying on a combination of...

We study the molecular pathways that regulate T cell function in the tumor microenvironment, with an emphasis on developing novel mechanistic insights that lead to the development of the next generation of cancer immunotherapies. We integrate analysis of...

Our group is devoted to investigating the way in which the functional, chemical and structural plasticity of neurons contributes both to the normal function and diseases of the nervous system. Our major efforts are devoted to the study of somatosensory...

Immune cells play important roles in retinal vascular development/remodeling/repair and degeneration. Immune dysregulation during these processes in the eye leads to diseases such as retinopathy of prematurity and age-related macular degeneration. Our...

We are interested in interactions between the two fundamental cell types of the nervous system, neurons and glia. My laboratory seeks to understand how neuron-glia communication facilitates the development and plasticity of synapses - the points of...

Innate and neuro-immune control of allergic immunity

The innate immune system plays a central role in adaptive immune initiation by sensing microbial invasion and environmental stress and using that information to promote specific adaptive immune...

Inflammation and Memory as Drivers of Barrier Tissue Ecology

Our goal is to understand the principles of how inflammation drives memory formation in human barrier tissues, in order to program and re-program them in disease. We are developing a training...