The Wheeler Lab investigates how immune system interactions with the nervous system influence behavior, inflammation, and tissue plasticity in the brain and peripheral organs. Our research spans three major themes:
(1) Immune and nervous system...
Our goal is to understand the role of neural-immune interactions in pain, host defense, and immunity. It is increasingly clear that microbes and immune cells release mediators that impact the health and function of the nervous system. Neurons also release...
Our lab works in the broad fields of T cell differentiation, immunological tolerance, autoimmunity and inflammation, translating mechanistic studies on mouse models to normal and diseased humans. Studies on T cell differentiation focus on maturation and...
Our lab has several interests, generally organized around the genetic and genomic control of immunological tolerance and autoimmune diseases. We study how T cells differentiate into different lineages in the thymus, and how the Aire transcription factor...
The major scientific interest of the Butovsky lab is to understand the biology of resident microglia and peripheral innate immunity in brain homeostasis and neurodegenerative conditions. The ultimate goal is to identify microglia- and monocyte-based...
The human intestine is exposed to a vast array of molecules from the microbiome, diet, and pathogens. The Nagashima lab focuses on three branches of research topics, all of which attempt to understand the gut immune system at the level of molecular...
In the Kuchroo laboratory, our overarching goal is elucidating the mechanisms that regulate immune functions in health, aging and different disease contexts. We focus on the functions of different CD4+ T helper subsets, and the role of costimulatory...
The core mission of The Majzner Laboratory is to leverage discoveries in basic immunology and cancer biology to develop and test new immunotherapeutics in children and adults with cancer. Our research program focuses on three core areas: 1) Developing...
Sensory information from the environment drives reflexive and motivated behaviors in all organisms. The types of information that are detected, how this information is coded by neural circuits, and the responses that they trigger are thus fundamental to...
