Overview:
Our studies seek to leverage new tools capable of defining the dynamic nature of cell surface glycans on immune cells and microbes. This approach has provided insight into the role of glycans in immune cell development and differentiation, in...
Our laboratory focuses on the engineering of human monoclonal antibodies for their use in discovery research and as drugs for the treatment of human diseases. We are working in two broad disease areas: emerging infectious diseases and cancer. We have...
A major area of our interest is how eukaryotic cells sense and respond to stress in the form of damage to their genetic material. When cells incur DNA damage, they induce the transcription of genes involved in cell cycle arrest and repair of the damage...
Our goal is to understand the role of neural-immune interactions in pain, host defense, and immunity. It is increasingly clear that microbes and immune cells release mediators that impact the health and function of the nervous system. Neurons also release...
Autoimmune Disease Deconstruction:
We have implemented a disease deconstruction pipeline using single cell and spatial technologies applied to inflamed tissues in humans to discover new cell types, cell states and pathways that mediate autoimmune disease...
The Pishesha Lab studies the biological complexities of antigen processing and presentation. We explore how these processes can be manipulated to modulate immunity. To that end we use engineered nanobodies and -for some applications- engineered red blood...
The human intestine is exposed to a vast array of molecules from the microbiome, diet, and pathogens. The Nagashima lab focuses on three branches of research topics, all of which attempt to understand the gut immune system at the level of molecular...
The Garrett Lab is interested in defining the dynamic interactions between the mucosal immune system and gut microbiota. Our experimental questions are grounded in understanding how interactions between intestinal microbial communities and the immune...
Hemostasis and Immunity Laboratory
Our laboratory aims to understand the role of the hemostatic factors (i.e., coagulation and fibrinolytic factors) in regulating inflammation at the mucosal barrier sites. The hemostatic and inflammatory systems have...
Sensory information from the environment drives reflexive and motivated behaviors in all organisms. The types of information that are detected, how this information is coded by neural circuits, and the responses that they trigger are thus fundamental to...
