Human

The Aster laboratory primarily studies Notch signaling in cancer. Ongoing projects seek to understand through use of ChIP-Seq and other comprehensive genome-wide approaches how Notch regulates the genomes of leukemia cells; how Notch activity is...

Messenger RNA is in constant flux between different locations and states -- the nucleus and cytoplasm, activation and silencing, translation and decay. Classical nuclear bodies such as nucleoli and nuclear speckles are self-generated RNA structures whose...

Research in the Anderson Laboratory focuses on understanding the pathways and mechanisms that regulate the T cell response in chronic disease, particularly in cancer. Specific areas of investigation are examination of the role of co-inhibitory/immune...

We are interested in elucidating the mechanisms controlling immune privilege of tissue-resident stem cells and cancer stem cells.

Stem cells are crucial for tissue homeostasis and regeneration and, as a consequence, some have evolved mechanisms to cloak...

Sialic acid O-acetylation, Siglecs and the regulation of hematopoiesis and immunity We are particularly interested in a novel set of pathways in which Sialic acid acetyl esterase (SIAE) and inhibitory receptors of the Siglec family regulate adaptive...